Scotland captain Stuart McInally has recovered from a calf injury to return to the side ahead of their Test against Argentina.
He is one of eight changes to the side, seven of which are among the forwards, with only Tim Swinson retaining his place from the shock 30-29 loss to the United States.
Allan Dell and Simon Berghan return to the front row alongside McInally, and Swinson will be partnered at lock by Grant Gilchrist.
Fraser Brown, Magnus Bradbury and David Denton also come in as the new back-row trio.
Dougie Fife, who scored a late try against USA, is rewarded with a place in the starting line-up at the expense of Byron McGuigan in the only change to the backs.
Scotland head coach Gregor Townsend is happy with how the players have reacted to the loss during their preparations.
"We have to make it as competitive as possible, we are doing all we can to win"— Scottish Rugby (@Scotlandteam) June 21, 2018
Gregor Townsend talks about facing Argentina this Saturday and the eight changes made to the starting side. #AsOne pic.twitter.com/pOUAGxPqx9
"The players have responded well in training this week with focus, effort and accuracy. This is our last Test of the tour and we're determined to finish on a high," said Townsend.
"With the majority of the squad involved in two Tests, we believe that we'll be in a much better position in the future, having exposed more players to Test-level rugby, for the season ahead and beyond.
"We've learned a lot on this tour about this group of players. Now we have to use that learning to put in a very good performance to beat Argentina on their home patch."
Scotland: Stuart Hogg, Dougie Fife, Nick Grigg, Pete Horne, Blair Kinghorn, Adam Hastings, George Horne; Allan Dell, Stuart McInally, Simon Berghan, Tim Swinson, Grant Gilchrist, Magnus Bradbury, Fraser Brown, David Denton.
Replacements: George Turner, Jamie Bhatti, Zander Fagerson, Ben Toolis, Jamie Ritchie, Sam Hidalgo-Clyne, James Lang, Chris Harris.
|American League win home run-filled MLB All-Star game|
|Dragons lure Sims from Broncos|
|Cassano: Ronaldo like Nadal, Messi like Federer|
|Lakers´ Ball undergoes successful knee surgery|
|´We kill them, Messi or no Messi´ - Pogba´s pre-Argentina World Cup speech revealed|
|Cardinals suspend GM Keim for five weeks after DUI|
|Dalic: I can coach Brazil or Barca but Croatia my favourite|
|Warriors coach Kerr extends contract|
|I´m ready to bust him up - Miller calls out Joshua after New York confrontation|
|CAF Champions League Review: ES Tunis and TP Mazembe set the pace|
|Mixed day for seeds in Newport as Muller progresses|
|Rams sign Cooks to five-year extension|
|Cowboys’ Randy Gregory reinstated by NFL|
|Verdasco survives Swedish Open scare as Paire is picked off in Umag|
|US Open announces record prize fund for 2018|
|Stosur wins battle of former grand slam champions in Gstaad|
|Emery is Arsenal´s best signing, says Pires|
|Brewster commits to Liverpool with long-term deal|
|Panama boss Gomez steps down after World Cup|
|No Chelsea agreement for Golovin, claims CSKA president|
|Root looks right at home as England ease to series victory|
|Brighton sign Mali midfielder Bissouma from Lille|
|Kaka backs Brazil boss Tite after ´excellent´ World Cup|
|Alaphilippe the toast in France as Van Avermaet increases Tour lead|
|Shkupi 0 Rangers 0: Gerrard´s men advance despite dour draw|
|Khazri ends Sunderland nightmare as Saint Etienne swoop|
|The Open 2018 diary: Rose lets Rio go as Rahm goes ´Lefty´|
|Lampard raids Chelsea and Liverpool in Derby double swoop|
|Balotelli returns to Nice training after Marseille talks stall|
|Owens wants to play in the CFL, says agent|
|I don´t like thinking too much - Johnson|
|Toulon president fined as French club receive suspended points penalty|
|Top of the flops - Mickelson plays exquisite trick shot over man´s head!|
|Kerber targeted Wimbledon after 2017 disappointment|
|England´s World Cup heroes given dedicated parking spots|
|Insigne prefers Messi to new Juve star Ronaldo|
|Koepka enjoys playing with a chip on the shoulder|
|Ryan Hall to leave Leeds Rhinos amid reports of NRL move|
|Hamann slams Lahm for Low criticism|
|Hart named in Manchester City squad for United States tour|
|F1 Raceweek: Leader Vettel heads home|
|Unfair to pin Brazil blame on Neymar, says Kaka|
|Thomas and friends ´want to beat each other´s brains in´|
|Woods´ love for links fathered at Carnoustie|
|Confident Rose targets tournament wins and number one spot|
|Hallgrimsson leaves Iceland post|
|Australian Open to consult players over fifth-set tie-breaks|
|Daley´s coming home - Ajax rewrite Three Lions anthem|
|Woods: Open my best chance at winning another major|
|Blind completes Ajax return from Manchester United|
|I belong at the top, says Anderson|
|Leaving Madrid was my biggest regret, Panucci warns Ronaldo|
|Folau in no rush to settle future amid Reds rumours|
|Degenkolb: I need two or three secretaries to manage congratulations!|
|Harrington v Garcia: When winning makes life tougher|
|Mafi and Timani fined by Rebels|
|Watson: Johnson and Woods can prosper at Carnoustie|
|Alderweireld hints at Tottenham departure|
|Maradona takes over as Dynamo Brest chairman|
|The Open 2018: Wounded animal Spieth is a danger to Carnoustie rivals|
|Wests´ Reynolds to miss the rest of 2018|
|Pussy Riot members jailed for World Cup final protest|
|Ronaldo capture boosts Serie A - Mourinho|
|Goals at three World Cups and 50 for the Socceroos – Cahill´s international career in numbers|
|Giroud: It´s coming home|
|Harper wins Home Run Derby in Nationals Park|
|Brighton sign Button from Fulham|
|Bolt set to trial with A-League club Central Coast Mariners|
|Thomas asks Seahawks for extension or trade|
|Walker doubts he´ll join Knicks, wants ´long´ stay at Hornets|