Roma's Alessandro Florenzi has a stomach bug and is a doubt to face Shakhtar Donetsk in the Champions League on Wednesday.
Versatile Italy international Florenzi, who typically plays on the right side of defence for Roma, has started 20 Serie A games out of 25 for Eusebio Di Francesco's side this season.
But illness could keep Florenzi out of the game and, with right-back Rick Karsdorp out long-term, Bruno Peres is an option to fill in, the Brazilian having been sent off against Atletico Madrid in the group stage.
Although Florenzi has travelled to Ukraine with the rest of the Roma squad, Di Francesco confirmed the 26-year-old is unable to train.
"Alessandro has stayed in the hotel because he's not well," the Roma coach told a pre-match news conference on Tuesday.
"Hopefully, he'll be available for selection but we'll have to see how he is tomorrow morning.
"If the game was today he wouldn't play and he won't train later either."
A change of formation and the form of Turkish forward Cengiz Under - the 20-year-old scoring four goals in three games - has helped Roma to three successive Serie A wins ahead of the Shakhtar tie.
But Di Francesco, while highly impressed with the youngster's performances, would not give any indication whether Under has earned a Champions League debut.
"Cengiz has been sensational lately - he's really come on in leaps and bounds," Di Francesco added. "He's been key for us but I prefer to focus on the team rather than individuals.
"It's Roma who are going out there to play tomorrow, not Cengiz. We're delighted to have him here and we'll try to exploit his talent as best we can.
"I'm not going to tell you who will play tomorrow. I want to keep all the lads on their toes and I want everyone to feel important and involved.
"We've significantly upped the intensity of our training sessions. It adds a small element of risk but the idea is to fill up the tank for the business end of the campaign and I hope to see the benefits on the pitch.
"We must play with grit, determination and belief – they're all things that can make a difference out there."
After knocking out Atletico Madrid in the group stage, many will expect Roma to come through their Shakhtar tie and reach the quarter-finals for the first time since 2007-08, but Di Francesco believes his side face a tough test.
"We've earned the right to be in the knockout stages and we want to make the most out of it now but we're up against a very talented team who are used to playing at this level," Di Francesco said.
"We have a 50 per cent chance of going through and hopefully we'll be able to take a good result back to Rome for the return. For now, though, we're focused solely on this game.
"We have to try and maintain a high tempo throughout the game. There will be times when we're in control of proceedings but we're up against a side who are very good in possession. We must stay strong as a unit.
"We've been looking a lot better recently and I hope to see further improvement tomorrow."
|Widnes defiant after Super League relegation, Saints outclass Wolves|
|NFL must go back to college to eradicate the tie|
|Real Madrid 1 Espanyol 0: Asensio downs old club to earn narrow win|
|Sampdoria 0 Inter 1: Brozovic wins it late after VAR takes centre stage|
|Rudy takes blame for James goal in Bayern win|
|Tiger charges into four-shot lead|
|Players have given their lives to Burnley - Dyche|
|QPR 0 Norwich City 1: Pukki hits winner as hot streak continues|
|Nuno proud of Wolves character in Man United draw|
|Playing for England my dream, says in-form Maddison|
|Brighton and Hove Albion 1 Tottenham 2: Kane on target as Spurs issue firm response|
|Schalke 0 Bayern Munich 2: James and Lewandowski deliver another win|
|Getafe 0 Atletico Madrid 2: Lemar inspires routine win|
|Championship Review: Monk ruins Leeds´ unbeaten streak, McGinn screamer fails to save Villa|
|Bale benched for Real Madrid-Espanyol|
|Biggar fails to rescue Saints at Bath, Bristol and Wasps win|
|Zaha affected by back injury – Hodgson|
|Mourinho slams Manchester United attitude after Wolves stalemate|
|Herbert holds Portugal Masters advantage|
|Warnock blasts ´elementary´ Cardiff mistakes|
|Shaqiri substitution not easy for Klopp|
|Guardiola hopes for even more to come from Aguero|
|Fellaini accepts United closing gap to Premier League summit will be difficult|
|Klizan to face Thiem in St. Petersburg final, Bachinger shocks Nishikori|
|Klopp: Van Dijk injury not serious|
|Mourinho annoyed by Man Utd´s blunt attack in Wolves draw|
|Valverde not ready to consider Barca contract extension|
|Gattuso wary of wounded Atalanta as Higuain receives further advice|
|Burnley 4 Bournemouth 0: Rampant Clarets claim first Premier League win of the season|
|Crystal Palace 0 Newcastle United 0: Sakho misses sitter as Magpies remain winless|
|Cardiff City 0 Manchester City 5: Aguero celebrates new deal with goal in 300th game|
|Leicester City 3 Huddersfield Town 1: Comeback win eases pressure on Puel|
|Liverpool 3 Southampton 0: Salah ends goalless run as Reds make best Premier League start|
|Manchester United 1 Wolves 1: Moutinho stunner sees Red Devils falter at home again|
|Rashid, Hasan and Asghar fined by ICC|
|Barnsley game postponed after medical emergency|
|Johnny Manziel sacked five times in ugly CFL loss|
|Fosu-Mensah says sorry for tackle on Deeney|
|Kluivert to get Roma chance as Di Francesco demands focus|
|Robinson optimistic injured Cronk will be fit for Grand Final|
|WATCH: Ferguson given immense ovation on Old Trafford return|
|Three in a row for Lorenzo at Aragon|
|Warner makes 155 on Australian grade cricket return|
|Pain-free Kyrie Irving ready to lead Celtics to NBA title|
|Firmino returns as Shaqiri gets first league start|
|Fulham 1 Watford 1: Mitrovic shines late to spoil Gray´s day|
|Ronaldo vows to lose weight and assist training after Real Valladolid purchase|
|Patriots WR Josh Gordon listed as questionable to face Lions|
|500th goal was crucial to my new book - Ibrahimovic|
|Roosters survive Cronk injury to hold off Souths and reach Grand Final|
|Murray announces intention to end season early|
|I want to play right-back for England - Walker|
|I would beat Bolt for speed on the pitch, claims Traore|
|Ferguson returns to Old Trafford for Manchester United v Wolves|
|Walker ´hurt´ by Pochettino claims over Tottenham exit|
|Douglas Costa has paid his fine for Sassuolo spitting incident – Allegri|
|Djokovic: Sock gave me karma back for hitting Federer|
|Anthony Joshua v Alexander Povetkin: Tale of the tape|
|Wang thrashes Putintseva to win Guangzhou title|
|There is no problem with Cavani - Tuchel silences rumours of PSG rift|
|Wilder & Fury sign contracts for December 1 bout|
|Neymar is the Kim Kardashian of football, claims Barton|
|We did not want to sell him - Perez insists Madrid got ´highest value´ for Ronaldo|
|Osaka continues run, Pliskova awaits in Tokyo final|
|Cardinals keep pace in wildcard race with win over Giants|
|Djokovic hits Federer, pair lose in doubles at Laver Cup|
|Nowitzki likely to come off bench for Mavericks in 21st season|
|Red Wings´ Green battling ´virus that attacked his liver´|
|They said I couldn´t score goals – Ibrahimovic hits back at early critics|
|Slater charged, set to miss Grand Final|