Sam Simmonds will start for England at number eight for the first time as one of nine changes Eddie Jones has made to his team for their final Autumn international against Samoa.
England have already beaten Argentina and Australia at Twickenham this month and will be looking to complete a clean sweep on Saturday.
Maro Itoje returns to the team at blindside flanker, prompting Chris Robshaw to move to openside.
Simmonds will take over from Wasps' Nathan Hughes, who is out with a bruised knee.
In the front row, Ellis Genge and Jamie George come in for Mako Vunipola and skipper Dylan Hartley.
With Hartley omitted from the starting line-up, Robshaw and fly-half George Ford will act as co-captains.
Charlie Ewels starts in the second row, Alex Lozowski and Henry Slade are paired together at centre and Mike Brown returns from concussion at full-back.
Danny Care will play at scrum-half as Ben Youngs drops to the bench.
"This is an exciting squad to play against Samoa and we are expecting them to be immensely physical and committed this weekend," Jones said in a statement on England's website.
"We want to follow up last week’s performance against Australia and play better again this week. Our intent in every game and every training session is to be better.
"This week it is an opportunity for some squad members who haven’t been playing to put their best foot forward. We will have to play smart and will need to find ways to win the contest against Samoa."
England: Mike Brown, Jonny May, Henry Slade, Alex Lozowski, Elliot Daly, George Ford, Danny Care; Ellis Genge, Jamie George, Dan Cole, Joe Launchbury, Charlie Ewels, Maro Itoje, Chris Robshaw, Sam Simmonds.
Replacements: Dylan Hartley, Joe Marler, Harry Williams, Nick Isiekwe, Courtney Lawes, Ben Youngs, Piers Francis, Semesa Rokoduguni.
|He´s one of the best – Simeone showers Oblak with praise|
|Juventus won´t sell in-demand Pjaca, agent claims|
|Bolasie in line for Everton return after long-term injury|
|Bedene to switch back from Britain to Slovenia|
|Maradona told Real Madrid to sign Mbappe|
|Samuels out of NZ tour, Narine to miss T20s|
|Sydney FC 3 Melbourne City 1: Champions come from behind to go eight points clear|
|Red-hot Salah wins Player of the Month|
|Heynckes unaware of reported Sanches loan termination|
|Maradona: I´d have won more Ballons d´Or than Ronaldo and Messi|
|Khawaja pleased to restore parity in Perth|
|Bairstow enjoys playful celebration of crucial century|
|The Ashes Round-up: Smith leading by example again|
|Wenger confirms Wilshere contract talks imminent|
|Sensational Smith leads Australia fightback|
|We´ve never been approached by Man United – Wenger rejects Ozil reports|
|Joshua ´absolutely´ capable of unification, says Klitschko|
|Mathews fit for India-Sri Lanka series decider|
|Lewandowski demands focus ahead of Christmas|
|Fury not rushing back to take on Joshua|
|Klopp right to rotate at Liverpool – Neville|
|Overton strikes twice for England in Perth|
|LeBron´s 59th triple-double leads Cavaliers past Lakers|
|Jets offensive coordinator admits surrender in blowout loss to Broncos|
|Osweiler helps Broncos past Colts|
|England collapse to be all out for 403 in Perth|
|Donnarumma plays down Milan exit rumours|
|Barkley could leave in January – Allardyce|
|Siemian suffers shoulder injury, Osweiler in for Broncos|
|Pulisic voted youngest-ever male USA player of the year|
|Griezmann will be allowed to leave – Simeone|
|Steelers LB Shazier has begun rehabilitation process|
|Guardiola appears to aim another dig at Mourinho|
|Vardy relishing Fleetwood return|
|Pau stay perfect with win over Agen|
|USB joking? Klitschko stick and robe sold for mega money|
|Almiron blocked from becoming Las Palmas coach|
|Ligue 1 adopts VAR from next season|
|Calabria extends AC Milan contract|
|Everton give new deals to Calvert-Lewin, Holgate & Kenny|
|Gooch backs Cook to rediscover England form|
|Itoje could return before Six Nations|
|Under-fire Hughes promises results will come for Stoke|
|Mourinho asked to explain pre-Manchester derby comments|
|Stoger sets Dortmund end of year target|
|Dyche: No swaggering from high-flying Burnley|
|Watzke plays down Nagelsmann rumour as Dortmund plan for 2018|
|Guardiola´s record runs with Manchester City, Bayern Munich and Barcelona compared|
|Martin lashes out at ´double standards´ in Froome ´scandal´|
|Day two crucial for England´s Ashes chances - Gooch|
|Benteke goal drought a concern for Hodgson|
|Nibali to skip 2018 Giro to focus on Tour|
|City look frightening – Rose|
|Kahn regrets rejecting Manchester United|
|Ireland scrum-half Marmion commits to Connacht|
|Giants president Mara wants Manning back for 2018|
|Malan pleased to silence the doubters with maiden century|
|No Australia involvement in fixing allegations - Paine|
|Bayern wrapping up Ribery for Christmas|
|Wilshere no closer to signing fresh Arsenal contract|
|Resurgent Rooney has Europe´s best shot-conversion record|
|Froome fears salbutamol stigma for asthma sufferers|
|Pastore bullish over PSG chances against Madrid|
|Paine calls on Australia to trigger England collapse|
|Independiente boss overjoyed by ´dream´ Copa Sudamericana success|
|Malan ´over the moon´ with first Test century|
|Silva is an animal - Guardiola|
|The Ashes Round-up: Malan´s maiden hundred steals the show|
|Malan and Bairstow shine as England prosper in Perth|
|Hewitt to come out of retirement at Australian Open|