Novak Djokovic's French Open preparations were dealt another blow in Barcelona as Martin Klizan recorded a 6-2 1-6 6-3 victory in the second round.
Twelve-time grand slam winner Djokovic was a late addition to the draw following his third-round exit in Monte Carlo last week, but his stay in Catalunya proved even shorter.
An inspired Klizan performance in the first set put the world number 140 in control and, although Djokovic clinched the second, the 28-year-old settled the match with a single break in the decider.
The result represents a first win for Klizan over Djokovic, who appeared to have accepted his fate late in the third.
Klizan's winning of the first point was met by a roar from a section of the crowd and the Slovakian's fans would have plenty more to celebrate.
The five-time winner on the ATP Tour won that opening game on Djokovic's serve with a fierce forehand down the line and, after surviving a break point to move 3-1 in front, Klizan stretched his lead yet further.
Klizan was giving the former world number one the run-around and a sublime drop shot wrapped up the sixth game, before he clinched the set with an ace.
Djokovic appeared to have settled early in the second set and made a crucial break to go 3-1 up, the Serbian displaying the range of shots his opponent had stunned him with in the opener.
Another break - to love, this time - confirmed Djokovic had found his stride, and one more without conceding a point pulled him level with Klizan.
The underdog battled to an important hold in the opening game of the deciding set but cut a frustrated figure after firing off a wayward shot in the sixth, throwing his racket at the clay in dismay.
His frustration was misplaced, however, as a couple of sloppy Djokovic errors led to a decisive break that allowed Klizan to serve out the match.
|Spain 2 England 3: Kane inspires Three Lions as Sterling ends drought in style|
|Bosnia-Herzegovina 2 Northern Ireland 0: Dzeko double leaves O´Neill´s side on the brink|
|Mannarino stops the rot in Moscow|
|Neymar pleased Brazil will not face Messi in Argentina clash|
|Buccaneers fire defensive coordinator Mike Smith after loss to Falcons|
|´Surprised´ Deschamps accepts he could´ve made more effort with Koscielny|
|Kuwait 0 Australia 4: Socceroos deliver win for new coach Arnold|
|Van Dijk fit for Liverpool return - Koeman|
|NBA 2018-19: Eastern Conference predictions|
|NBA 2018-19: Five rookies to watch|
|Denly replaces injured Dawson in England ODI squad|
|Low confirms under-fire Neuer to start against France|
|NBA 2018-19: Western Conference predictions|
|Bolt offered two-year deal by European club, says agent|
|NBA 2018-19: LeBron the Laker - what it means|
|Griezmann ahead of Mbappe for Ballon d´Or - Modric|
|Billy Vunipola ruled out with fractured arm|
|Get the chequebook out! - Mayweather talks up potential Khabib clash|
|Amla ruled out of Australia tour|
|Class act Hamilton more complete than ever - Wolff|
|NBA 2018-19: It´s a big season for - Ball, Kawhi, Carmelo, Love & Cousins|
|Bellew: I have no fear of Usyk|
|Birthday boy Ozil is the most creative player in Europe|
|CSA reveals De Villiers and Rabada involved in Mzansi Super League|
|FA condemns England supporters involved in trouble in Seville|
|Gascoigne hits back over Scottish Hall of Fame snub|
|NBA 2018-19: LeBron closing in on Jordan, Curry chasing Miller and Allen|
|Ter Stegen should start ahead of Neuer for Germany – Matthaus|
|England´s Sterling impressed by Sancho´s work ethic|
|Vandoorne seals switch to Formula E|
|Halep to end 2018 as world number one|
|Sri Lanka´s Jayasuriya charged by ICC with breaching anti-corruption code|
|Vermaelen out for six weeks with hamstring injury|
|LeBron and Irving did not fall out, says ex-Cavs trainer|
|Ramsey out of Wales´ clash with Republic of Ireland|
|Bolt angry with drugs test|
|Bad luck is not a coincidence – Kimmich concerned by Germany form|
|Mahomes: Chiefs need to win like Brady and the Patriots|
|Schuster warns Real Madrid not to panic-buy striker in January|
|We´re here to win! - Paine not happy celebrating a draw|
|Injured Thauvin out of Germany clash|
|Southgate hits out at early Premier League start|
|Modric to Inter talk is ´fantasy´, says Guardiola|
|Pats hand first loss to Chiefs after wild shoot-out|
|Cowboys, Ravens dominate as Pats beat Chiefs in NFL classic|
|Brady becomes first QB to 200 regular-season wins in NFL|
|Red Sox level series against Astros|
|Mbappe leaves red-faced Dembele on his backside|
|Red Sox ace Sale admitted to hospital with stomach illness|
|From UFC to NFL? McGregor throws pass for Cowboys|
|Ancelotti praises ´dangerous´ Mbappe|
|Uncapped Papalii named in All Blacks squad|
|Kane would star in LaLiga – Ramos|
|Guardiola unsure about Man City´s Champions League chances|
|Dzeko: Premier League return? You never know|
|Gurley dominates to help Rams beat Broncos|
|Butler expected to play Timberwolves´ opener against Spurs|
|I´m no wizard – Mancini asks for patience with Italy|
|The Messi and Ronaldo era is phenomenal – Guardiola|
|Dolphins defeat Bears in OT with 47-yard field goal|
|Almirola picks up win at Talladega|
|Wigan´s Sarginson wanted Grand Final glory in memory of brother|
|McLeish: Scotland keep shooting themselves in the foot|
|Sarries´ walking wounded a concern for Jones|
|Poland 0 Italy 1: Biraghi seals last-gasp win to keep final-four hopes alive|
|Seahawks top Raiders with blowout win in London|
|In-demand Hogg hints at Glasgow exit|
|Holder calls on Windies batsmen to step up after India whitewash|
|France´s World Cup win hurt me - Koscielny retires from international football|
|Bailey performs U-turn on Jamaica call-up|