Last season's beaten finalists Liverpool come up against the might of Paris Saint-Germain as the Champions League returns to mouth-watering action on Tuesday.
Anfield will be rocking for the arrival of Neymar and Kylian Mbappe as Jurgen Klopp's side look to get off to a flier in a tricky group, which also contains Napoli and Red Star Belgrade.
Tottenham and Inter will both be aiming to put testing league campaigns behind them when they do battle at San Siro - with Harry Kane on course to join an elite group - while in Group B's other game PSV face a daunting trip to Barcelona.
In the night's other standout tie, Radamel Falcao will hope to get one over his former employers as Monaco host Atletico Madrid in Group A.
Below, we examine the key Opta numbers behind Tuesday's matches.
Barcelona v PSV
24 - Barcelona have won 24 of their last 26 Champions League games at the Camp Nou (W24 D2 L0), with their last defeat there dating back to May 2013 against Bayern Munich (0-3).
9 - Current PSV coach Mark van Bommel made nine Champions League appearances for Barcelona between September 2005 and May 2006, including playing 61 minutes in the Spanish team's victory over Arsenal in the 2006 Champions League final.
Inter v Tottenham
7 - After qualifying for the competition for 10 successive years between 2002-03 and 2011-12, Inter will be competing in the Champions League for the first time in seven years, their longest wait since the rebranding of the tournament in 1992-93 (also seven between 92-93 and 98-99).
9 - Tottenham striker Harry Kane has scored nine goals in 10 Champions League appearances so far in his career. The fastest players to 10 Champions League goals are Adriano, Sadio Mane and Roberto Firmino (11 appearances) – Kane could equal this if he scores in his first Champions League appearance of 2018-19.
Club Brugge v Borussia Dortmund
6 - Only Benfica (7) are on a longer current losing run in the Champions League among sides in this season's competition than Club Brugge (6).
12 - Borussia Dortmund's Marco Reus has scored 12 goals and delivered four assists in his last 16 Champions League games.
Schalke v Porto
23 - Porto have made it to the Champions League group stages for the 23rd time, which equals the record held by Barcelona and Real Madrid. They haven't progressed further than the quarter-finals since they lifted the trophy in 2004.
5 - Schalke have reached the knockout stages of the Champions League in each of their previous five appearances, with their best performance dating back to 2010-11 (semi-finals).
Monaco v Atletico Madrid
14 - Monaco have failed to keep a single clean sheet in their last 14 Champions League games, the longest current run of sides taking part in the 2018-19 edition of the competition (Galatasaray also 14).
6 - This is Atletico's sixth consecutive Champions League campaign, the longest run in their history. They were beaten finalists in 2013-14 and 2015-16, while being eliminated in the quarter-finals in 2014-15 and semi-finals in 2016-17.
Liverpool v Paris Saint-Germain
8 - Last season, Liverpool's James Milner (8) equalled the record set by current PSG star Neymar (8 in 2016-17) for the most assists by a player in a single Champions League campaign since 2003-04.
8 - PSG striker Edinson Cavani has scored eight goals in 14 appearances in the Champions League against teams from England.
Red Star Belgrade v Napoli
8 - Red Star Belgrade have not won any of their previous eight matches in the European Cup/Champions League against sides from Italy (D4 L4), including losing each of the last two, both to Sampdoria in the 1991-92 group stage.
12 - Napoli were knocked out of the Champions League despite amassing 12 points in the 2013-14 group stages, the highest points total to see a side eliminated since the new format in 2003-04 (finished third behind Arsenal and Borussia Dortmund).
Galatasaray v Lokomotiv Moscow
2 - Galatasaray goalkeeper Fernando Muslera has kept only two clean sheets in 27 Champions League games.
26 - Yuri Semin has taken charge of all 26 Champions League games played by Lokomotiv Moscow (2001-02, 2002-03 and 2003-04).
Şampiyonlar Ligi D Grubu 1. maçında, yarın saat 22:00’de Lokomotiv Moskova ile oynayacağımız maçın bilet satışı devam ediyor...— Galatasaray SK (@GalatasaraySK) September 17, 2018
Bilet satın almak için https://t.co/4AEaHGYsJy
Detaylar https://t.co/6xUOP20Ong pic.twitter.com/sRbX7O52eq
|WRC great Loeb seals Hyundai switch|
|Madrid rumours better than sack talk, says Pochettino|
|Nadal to join Federer at 2019 Laver Cup|
|Prigoda smashes world record, Hosszu dethroned in Hangzhou|
|Former Juve CEO Marotta takes over at Inter|
|Glenn to stand down as FA boss next year|
|Muller apologises to Tagliafico for kick to the head|
|Pereira pleads for more Manchester United chances|
|Griffin hails ´phenomenal´ Lowry after Warriors demolition|
|I´ve played with Zidane and Henry, but Messi is something else – Pires|
|Dragons forward Jack de Belin charged with sexual assault|
|Durant: Raptors are the real deal|
|Cocu bids farewell to Fenerbahce after ´mutual agreement´ is made over October sacking|
|Australia unchanged for historic Perth Test|
|Champions League draw: The possible last-16 ties|
|Southee happy to be back on home soil|
|I wouldn´t swap Dembele for Neymar – Pires|
|Canelo ready to risk heavy weather against Fielding|
|Raptors upstage Warriors, Davis leads Pelicans with 44 points|
|India skipper Kohli excited by green Perth wicket|
|PSG? I haven´t decided my future yet – De Jong|
|Marcelo: Real Madrid don´t have attitude problem|
|India pair Ashwin, Rohit ruled out of second Test|
|Kovac: Ajax-Bayern draw was amazing|
|Sims re-signs with Dragons until 2022|
|Derrius Guice injury update: Redskins RB (knee) has rehab setback, undergoes 3 more procedures|
|Emery: Arsenal could sign defender in January|
|Phillies sign McCutchen to three-year deal|
|O´Neal thinks his Lakers teams could ´easily´ beat Warriors|
|A-League to add two clubs by 2020|
|Curry says he was ´obviously joking´ about moon landing comments|
|Now the beautiful part starts – Ronaldo ready for Champions League knockout stage|
|Bayern have a lot more potential – Lewandowski not satisfied despite top spot|
|Lyon star Fekir shares plaudits for Champions League progression|
|Mourinho not surprised by United´s defeat to Valencia|
|Motivation no issue for Benfica, claims Vitoria|
|Lewandowski finishes Champions League group stage as top scorer|
|Mourinho: We scored two goals and lost 2-1!|
|England have a diamond - Guardiola hails City´s Foden|
|Sterling´s carefree display invites us to love football more than others hate|
|Juventus achieved their objective, despite everything going wrong – Allegri|
|Never say never - Schmidt not ruling out All Blacks role|
|Bologna´s winning start ended in BCL|
|Di Francesco critical of Roma performance|
|Shakhtar Donetsk 1 Lyon 1: Fekir fires French side through in Group F|
|Benfica 1 AEK Athens 0: Grimaldo sends hosts out on a high|
|Young Boys 2 Juventus 1: Hoarau double seals famous victory|
|Manchester City 2 Hoffenheim 1: City through as group winners after Sane brace|
|Ajax 3 Bayern Munich 3: Kovac´s men clinch top spot in Amsterdam thriller|
|Valencia 2 Manchester United 1: Jones scores own goal as Red Devils limp through|
|Solari accepts responsibility for Madrid´s heaviest home defeat in Europe|
|WATCH: Rooney backs Rocky ahead of Canelo showdown|
|McLaren to collaborate with Team Bahrain Merida|
|Las Vegas to host 2020 NFL Draft|
|Stade teenager tragically dies after neck injury|
|Cahill may need to leave Chelsea if he wants to play, admits Sarri|
|Viktoria Plzen 2 Roma 1: Chory winner takes hosts into Europa League|
|Real Madrid 0 CSKA Moscow 3: Champions humiliated at Bernabeu|
|Sarri condemns ´disgusting´ Sterling abuse|
|Hansen hails outstanding Ben Smith ahead of Pau switch|
|Foden, Sterling start for Manchester City v Hoffenheim|
|Sky decision will not affect us in 2019, insist Froome and Thomas|
|Al Ain 3 Team Wellington 3 (aet, 4-3 on penalties): Shootout heartbreak for semi-pros in Club World|
|Jackson to remain Ravens´ starting QB despite Flacco return|
|Rams headline 2019 NFL International Series home teams|
|Rams headline International Series home teams for 2019|
|Atlanta want ´exciting football´ from new boss amid Bielsa links|
|Atlanta still yet to receive ´serious´ bid for ´Bale-like´ Almiron|
|Tottenham v Manchester United to be held at Wembley|
|Matip facing six weeks out with fractured collarbone|