Arsenal midfielder Jack Wilshere will miss England's friendly against Netherlands in Amsterdam on Friday with a tendon problem.
Wilshere was in line for a first international appearance since Euro 2016, having battled back from persistent injury issues to regain a place in Arsene Wenger's first-team plans this season.
Speaking at a pre-match news conference, England boss Gareth Southgate played down fears the 26-year-old's latest setback was significant, and Wilshere could still feature when Italy travel to Wembley next week.
"Jack just felt some tendinopathy in his knee," Southgate said. "It's a problem he's had before, nothing too serious.
"We had the option to bring him here and treat him here but we've decided to have him back at base.
"There's a good chance he's with us on Saturday but we'll see how he responds.
"It's something that in the past has settled down very quickly so hopefully that will be the case. Lots of players have tendon issues that over time flare up.
"He's trained well with us this week and if you think about the journey he's been on over the last couple of years, the big injuries he's had to come back from. He's progressing really well."
We've arrived in the Netherlands, where Gareth Southgate has confirmed that @JackWilshere hasn't travelled – but the @Arsenal man remains in contention for Tuesday's game against Italy. pic.twitter.com/eDwwQ5pmWH— England (@England) March 22, 2018
Southgate confirmed Everton goalkeeper Jordan Pickford will start against Netherlands, filling a role that has unhelpfully become a problem position as the 2018 World Cup approaches.
Joe Hart only recently regained his first-team spot at West Ham after being dropped in December, while Stoke City's Jack Butland is also shy of his best form and in the midst of a relegation fight.
Uncapped Burnley keeper Nick Pope is in the squad for the first time – his opportunity in Sean Dyche's side have only come about due to still-sidelined England international Tom Heaton suffering a dislocated shoulder against Crystal Palace last September.
Pickford impressed in November's goalless draw with Germany and he will get a chance to shine once more when Ronald Koeman – the man who sanctioned a £30million move for the former Sunderland keeper while manager at Everton – takes charge of his country for the first time.
"He's a very agile keeper who is quick around his goal and capable of making big saves," Southgate said.
"His distribution is excellent which is a key part of how we want to play.
"It's a great opportunity for him. He played really well against Germany in November and it's another good opportunity for us to see him in another international game."
|Curry ´questionable´ for Pelicans game one - Kerr|
|You´ve got to have balls - Simeone hails defiant Atletico|
|Wenger refuses to blame Koscielny for Griezmann goal|
|Muguruza reveals back injury forced Stuttgart retirement|
|Marseille still underdogs against Salzburg, says Payet|
|Wenger rues ´worst possible´ goal from Griezmann|
|Griezmann: Oblak is the best goalkeeper in the world|
|Besiktas refuse to complete abandoned Fenerbahce semi-final|
|´Better mentality´ key to improved Nadal showing|
|Barba injury threatens to overshadow Saints´ rout of Salford|
|Marseille 2 Red Bull Salzburg 0: Thauvin, N´Jie earn semi-final advantage|
|Arsenal 1 Atletico Madrid 1: Griezmann smuggles vital away goal for 10-man Atleti|
|Woods to return at Wells Fargo Championship|
|Hamilton: Respect between Vettel and I has grown|
|Mourinho: Chelsea sold Salah, not me|
|Vrsaljko and Simeone sent off in dramatic start to Arsenal v Atletico|
|Kerber and Muguruza retire from Stuttgart Open|
|Khan planning major Wembley refurbishment if bid is accepted|
|Panthers respond to alleged Jerry Richardson victim´s expose|
|Cazorla trains at Emirates after injury agony|
|Kings XI crumble as Rashid spins Sunrisers to success|
|Costa makes Atleti bench as Ozil returns for Arsenal|
|Wozniacki´s comeback edges out Errani|
|Dimitrov fends off match points as Nadal cruises through|
|Two men remanded in custody over Liverpool fan attack|
|Sweet 16 for Nadal in swatting aside Garcia-Lopez|
|Liverpool book ´extraordinary´ Rome meeting to plan fan safety|
|Burnley confirm Arfield, Marney departures|
|Under-fire Montella acknowledges Sevilla in ´very bad´ form|
|Wilder jibe motivated Fury to embark on road to recovery|
|Jerome Boateng to ´fight´ for World Cup place after season-ending injury|
|Luckless Roland-Jones out for the season|
|Ricciardo denies Ferrari rumours|
|Khan won´t relocate England national teams if Wembley bid is accepted|
|Additional World T20 to replace Champions Trophy in 2021|
|Ibrahimovic will not play at the World Cup, says Swedish FA|
|Oates inspires Broncos victory over Rabbitohs|
|FA confirms offer made to buy Wembley Stadium|
|Quarterback-needy teams must drown out noise of NFL´s silly season|
|Betis would welcome Ceballos back with open arms – Joaquin|
|Turkey submits Euro 2024 bid to rival Germany|
|Meyer ´definitely´ leaving Schalke, confirms Heidel|
|Rank outsider Jin leads China Open|
|Buffon apologises for snubbing fans after Napoli defeat|
|Semenya appears unimpressed with IAAF hyperandrogenism rule|
|UEFA charges Bayern Munich over pitch invasion and banner|
|Police charge two over Liverpool fan attack|
|Shields in the dark over England availability|
|Hearn: Wilder´s $50million Joshua offer a PR move|
|Bayern were naive and reckless – Kimmich|
|Salah a nightmare to train against – Alexander-Arnold|
|Ramos: If Iniesta was Andresinho, he would´ve won Ballon d´Or|
|Marlins upset Kershaw, Dodgers to win first series|
|Thunder overturn 25-point deficit to avoid elimination, LeBron buzzer-beater lifts Cavs|
|Guadalajara 1 Toronto 2 (3-3 agg, 4-2 on pens): Mexican hosts win CONCACAF Champions League|
|Hawks, coach Mike Budenholzer part ways|
|Copa Libertadores Review: Palmeiras advance, Nacional claim crucial win|
|WATCH: LeBron James sinks three for buzzer-beating win|
|I´m the best defender in Serie A, says Inter´s Miranda|
|Real Madrid still relying on Bale – Zidane|
|´I don´t f****** want to´ – Harvey refused to talk about bullpen debut|
|Wilder´s camp extends $50m offer for fight with Joshua|
|Ramos: Madrid were expected to win 3-0 but Bayern are difficult|
|Boateng casts doubt over Bayern future|
|Salah a Ballon d´Or contender, says Lovren|
|Muller demands killer mentality from Bayern at Bernabeu|
|Cavs´ Hill ruled out of game five with back spasms|
|Kimmich: Bayern should have beaten Madrid 7-2|
|Brewers´ Thames placed on DL with torn thumb ligament|
|Heynckes: We gave Real Madrid two goals|